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Microscopic examination was performed using a Leica DM500 at 40 magnification, and photomicrographs documented epidermal changes, dermal fibroblast density, vascularization, collagen organization, and inflammatory infiltrates across study groups 50

Summary of Key Points Bottom line: Taking Vitamin C while on Accutane is widely considered safe and may help reduce skin irritation, provided you choose a bioavailable oral form rather than an acidic topical one

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J Chromatogr B 877:12291239 Kon K, Kim J-S, Jaeschke H, Lemasters JJ (2004) Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytes